A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection.
نویسندگان
چکیده
Interleukin-6-deficient (IL-6(-/-)) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6(-/-) mice. IL-6 is needed for an optimal early host response to this infection.
منابع مشابه
Role of natural killer cells in infection with the mouse pneumonitis agent (murine Chlamydia trachomatis).
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ورودعنوان ژورنال:
- Infection and immunity
دوره 66 9 شماره
صفحات -
تاریخ انتشار 1998